When genes are expressed - turned on, off, up or down - at the wrong time or in the wrong amounts, it alters the function of a cell, leading to disease. By creating medicines to control the expression of genes that have gone awry in disease, we aim to make a profound difference in the lives of patients and their families. We are advancing a growing pipeline of investigational medicines that control the expression of disease-driving genes with the aim of providing a profound and durable benefit for patients with diseases that have largely eluded other genomics-based approaches. Our current focus is on cancer, including immuno-oncology, as well as autoimmune and genetic diseases.