RobertMDS Patient

The Right Expression Can Change a Life

When genes are expressed at the wrong time or in the wrong amounts, it alters the function of a cell, leading to disease. By developing small-molecule medicines to control the expression of genes, we aim to make a profound difference in patients’ lives. We are advancing a growing pipeline of investigational gene control medicines for diseases that have largely eluded other genomics-based approaches. Our current focus is on cancer and monogenic diseases.

Program Indication Discovery Preclinical Early Clinical Mid-Stage Clinical Pivotal Commercial Rights
SY-1425 (RARα agonist)
SY-1425 (RARα agonist)
Frontline AML (combination with azacitidine)
Discovery Phase complete
Preclinical Phase complete
Early Clinical Phase complete
Mid-Stage Clinical Phase in progress
Pivotal Phase not started
Syros (North America & Europe)
Syros (North America & Europe)
SY-1425 (RARα agonist)
Relapsed or refractory AML (combination with azacitidine)
Discovery Phase complete
Preclinical Phase complete
Early Clinical Phase complete
Mid-Stage Clinical Phase in progress
Pivotal Phase not started
Syros (North America & Europe)
SY-5609 (Oral CDK7 inhibitor)
SY-5609 (Oral CDK7 inhibitor)
Cancer
Discovery Phase complete
Preclinical Phase in progress
Early Clinical Phase not started
Mid-Stage Clinical Phase not started
Pivotal Phase not started
Syros (Global)
Syros (Global)
CDK12/13 Inhibitor
CDK12/13 Inhibitor
Cancer
Discovery Phase complete
Preclinical Phase in progress
Early Clinical Phase not started
Mid-Stage Clinical Phase not started
Pivotal Phase not started
Syros (Global)
Syros (Global)
Macrophage Target
Macrophage Target
Cancer
Discovery Phase complete
Preclinical Phase in progress
Early Clinical Phase not started
Mid-Stage Clinical Phase not started
Pivotal Phase not started
Syros (Global)
Syros (Global)
Discovery
Discovery
Cancer
Discovery Phase in progress
Preclinical Phase not started
Early Clinical Phase not started
Mid-Stage Clinical Phase not started
Pivotal Phase not started
Syros (Global)
Syros (Global)
Discovery
Sickle Cell Disease  
Discovery Phase in progress
Preclinical Phase not started
Early Clinical Phase not started
Mid-Stage Clinical Phase not started
Pivotal Phase not started
Syros (Global)
Discovery
Discovery
Myeloproliferative neoplasms
Discovery Phase in progress
Preclinical Phase not started
Early Clinical Phase not started
Mid-Stage Clinical Phase not started
Pivotal Phase not started
Incyte (Global)
Incyte (Global)

Interested in Participating in a Clinical Trial?

If you’re interested in participating in a clinical trial, check to see if a trial is open near your area and if you meet the requirements to participate.

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Partnership Opportunities

We seek partnerships that maximize value for us and our partners by extending the potential of our gene control platform across multiple therapeutic areas and diseases.

View Our Partnership Focus

Our Publications and Abstracts

Learn more about the science and data behind our platform and our programs.

Read Publications and Abstracts