AnneOvarian Cancer Survivor

An Expression Makes a World of Difference

The genes expressed - turned on, off, up or down - in any given cell determine its type and function. When the wrong genes are expressed at the wrong time or in the wrong amounts, it can lead to disease.


At Syros, we are redefining the power of small molecules to control the expression of genes, and in doing so, we aim to make a profound difference in the lives of patients and their families. Join us in understanding the coordinated expression of the Syros team in fulfilling our mission.

We Understand How the Expression of Genes Is Controlled

Regulatory regions of the genome control the expression of genes, turning them on, off, up or down, like dimmer switches and determining how a cell behaves. Because gene expression is fundamental to the function of all cells, alterations in these regulatory regions contribute to virtually all diseases. Until recently, however, scientists lacked the tools to study these regulatory regions, rendering them largely unexploited for drug discovery and development.

Ours is the leading platform focused on the regulatory genome to develop small-molecule medicines that control the expression of genes with the aim of addressing diseases that have eluded other genomics-based approaches.

Learn about our Gene Control Platform
RobertMDS Patient

Expressing the Power of Small Molecules in a Big Way

We are advancing a growing pipeline of small-molecule medicines that control the expression of genes to treat cancer and genetic diseases. Our pipeline includes two investigational medicines in clinical trials and multiple programs in preclinical development and discovery research.h.

View Our Programs

Our Programs

SY-1425

Driving Expression of Differentiation Genes

A first-in-class selective oral RARα agonist in a Phase 2 clinical trial in a genomically defined subset of patients with acute myeloid leukemia.

View SY-1425 Program

SY-5609

Decreasing Expression of Cancer-Driving Genes

A highly selective and potent oral CDK7 that is expected to enter a Phase 1 clinical trial in the first quarter of 2020 in patients with select solid tumors.

View SY-5609 Program

Passion is a Powerful Expression

Careers at Syros

Pioneers in Gene Control

Redefining the power of small molecules to control the expression of genes.

Learn More

Our Leadership

A team with a proven record of translating innovative science into important therapies.

Learn More

Spotlight

"I love being a part of a company that is so focused on transforming the lives of patients and making a positive impact on the community. It's hard to not get excited about all the amazing things Syros is doing from the science and research to our multiple fund-raising efforts, community service and initiatives to make the world a greener place. I'm so proud to be a part of all of that." - Janessa, Research Associate II

"The people, the culture and the passion at Syros makes me feel like we can achieve big things." - Nisha, Senior Scientist

"One of the things that makes Syros a great place to work is how approachable everyone is, including the management team. I really appreciate people's openness to discuss new ideas or concerns either in formal settings or while grabbing a cup of coffee." - Kristin, Scientist I

“When you put smart people together who are dedicated to a common cause in an environment that encourages teamwork and open communication, good things are going to happen. Syros is a stew of talent directed at significantly improving outcomes for patients with challenging diseases. I want to be a part of that – to contribute to success for Syros and for patients who need better alternatives.” - Charlie, VP of New Product Planning

Our Culture

Collaborative to our core and driven to make a difference for patients, we take on big challenges in our shared pursuit of big breakthroughs.

Learn More

Our Mission

Transforming lives through the creation of novel gene control medicines.

Learn More