AnneOvarian Cancer Survivor

An Expression Makes a World of Difference

At Syros, we are pioneering a new area of medicine focused on controlling the expression of genes. The genes expressed - turned on, off, up or down - in any given cell determine its type and function. By creating medicines to control the expression of genes that have gone awry in disease, we aim to make a profound difference in the lives of patients and their families. Join us in understanding the coordinated expression of the Syros team in fulfilling our mission.

We Understand How the Expression of Genes Is Controlled

Regulatory regions of the genome control the expression of genes, turning them on, off, up or down, like genomic dimmer switches and determining how a cell behaves, whether it is a skin cell or a lung cell, whether it is normal or diseased. Because gene expression is fundamental to the function of all cells, alterations in these regulatory regions contribute to virtually all diseases. But until recently, scientists lacked the tools to study these regulatory regions, rendering them poorly understood and largely unexploited for drug discovery and development.

We have built the first platform dedicated to the regulatory genome to systematically and efficiently identify disease-causing alterations in gene expression and develop medicines that control the expression of genes with the aim of providing a profound and durable benefit for patients with diseases that have largely eluded other genomics-based approaches.

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RobertMDS Patient

Advancing a New Wave of Medicines to Control the Expression of Disease-Driving Genes

We are advancing a growing pipeline of gene control medicines for cancer, autoimmune disorders and genetic diseases, including two investigational medicines in clinical trials and multiple programs in preclinical development.

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Our Programs

SY-1425

Driving Expression of Differentiation Genes

A first-in-class selective RARα agonist that we are investigating as both a monotherapy and a combination agent in a Phase 2 clinical trial in genomically defined subsets of patients with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS).

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SY-1365

Decreasing Expression of Oncogenic Transcription Factors

A first-in-class selective CDK7 inhibitor in a Phase 1 clinical trial in patients with transcriptionally dependent solid tumors, including triple negative breast, small cell lung and ovarian cancers.

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Passion is a Powerful Expression

Careers at Syros

Pioneers in Gene Control

Pioneering a new field of drug discovery and development to provide a profound and durable benefit for patients.

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Our Leadership

A team with a proven record of translating innovative science into important therapies.

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Spotlight

"I love being a part of a company that is so focused on transforming the lives of patients and making a positive impact on the community. It's hard to not get excited about all the amazing things Syros is doing from the science and research to our multiple fund-raising efforts, community service and initiatives to make the world a greener place. I'm so proud to be a part of all of that." - Janessa, Lab Operations Assistant

"The people, the culture and the passion at Syros makes me feel like we can achieve big things." - Nisha, Senior Scientist

"One of the things that makes Syros a great place to work is how approachable everyone is, including the management team. I really appreciate people's openness to discuss new ideas or concerns either in formal settings or while grabbing a cup of coffee." - Kristin, Senior Research Associate

"I'm excited about the promise of our medicines. I'm excited to be so intimately involved in the drug development process. I'm excited to see the growth and the development of the company and my colleagues. I'm excited about all the learning I get to do every day when I come to work." - Alex, Associate Director, Regulatory Affairs

Nancy Simonian, CEO, named 2017 Xconomy Award Finalist

Our Culture

Collaborative to our core and driven to make a difference for patients, we take on big challenges in our shared pursuit of big breakthroughs.

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Our Mission

Transforming lives through the creation of novel gene control medicines.

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