Decreasing Expression of Cancer-Driving Genes
SY-1365 is a first-in-class potent and selective inhibitor of the cyclin-dependent kinase 7 (CDK7) that is in a Phase 1 clinical trial as a single agent and in combination with standard-of-care therapies in multiple patient populations with ovarian and breast cancers.
SY-1365 represents a new approach to treating cancer that we believe has potential in a range of difficult-to-treat solid tumors and blood cancers. SY-1365 has demonstrated robust anti-tumor activity, including inducing complete regressions, in multiple preclinical models of cancer. In preclinical studies, SY-1365 has also been shown to preferentially kill cancer cells over non-cancerous cells and lower the expression of key cancer-driving genes.