RobertMDS Patient

An Expression Makes a World of Difference

The genes expressed - turned on, off, up or down - in any given cell determine its type and function. When the wrong genes are expressed at the wrong time or in the wrong amounts, it can lead to disease.

At Syros, we are redefining the power of small molecules to control the expression of genes, and in doing so, we aim to make a profound difference in the lives of patients and their families. Join us in understanding the coordinated expression of the Syros team in fulfilling our mission.

AnneOvarian Cancer Survivor

Expressing the Power of Small Molecules in a Big Way

We are advancing a clinical pipeline of small-molecule medicines that control the expression of genes to treat cancer and genetic diseases. Our pipeline includes three investigational medicines in clinical development and multiple programs in preclinical development and discovery research.

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Our Programs


A selective oral RARα agonist in clinical development for genomically defined subsets of patients with myelodysplastic syndrome and acute myeloid leukemia.

View Tamibarotene Program


A novel oral form of arsenic trioxide in clinical development for patients with acute promyelocytic leukemia.

View SY-2101 Program


A highly selective and potent oral CDK7 inhibitor in clinical development for pancreatic cancer and BRAF-mutant colorectal cancer.

View SY-5609 Program

We Understand How the Expression of Genes Is Controlled

Regulatory regions of the genome control the expression of genes, turning them on, off, up or down, like dimmer switches and determining how a cell behaves. Because gene expression is fundamental to the function of all cells, alterations in these regulatory regions contribute to virtually all diseases. Until recently, however, scientists lacked the tools to study these regulatory regions, rendering them largely unexploited for drug discovery and development.

Ours is the leading platform focused on the regulatory genome to developing small-molecule medicines that control the expression of genes with the aim of addressing certain cancers and monogenic diseases that have eluded other genomics-based approaches.

Learn about our Gene Control Platform

Passion is a Powerful Expression

Careers at Syros

Pioneers in Gene Control

Redefining the power of small molecules to control the expression of genes.

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Our Leadership

A team with a proven record of translating innovative science into important therapies.

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Forbes America's Best Small Companies

"I love being a part of a company that is so focused on transforming the lives of patients and making a positive impact on the community. It's hard to not get excited about all the amazing things Syros is doing from the science and research to our multiple fund-raising efforts, community service and initiatives to make the world a greener place. I'm so proud to be a part of all of that." - Janessa, Senior Research Associate

"The people, the culture and the passion at Syros makes me feel like we can achieve big things." - Nisha, Principal Scientist

"One of the things that makes Syros a great place to work is how approachable everyone is, including the management team. I really appreciate people's openness to discuss new ideas or concerns either in formal settings or while grabbing a cup of coffee." - Kristin, Scientist II

Our Culture

Collaborative to our core and driven to make a difference for patients, we take on big challenges in our shared pursuit of big breakthroughs.

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Our Mission

Transforming lives through the creation of novel gene control medicines.

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